The detailed analysis of biomarkers present in the breath is a new field of research for a non-invasive early detection of given diseases, in particularly of given cancers. This thesis is part of a project aiming at the development of a new diagnostic tool for clinician that would allow patient breath sampling and its analysis through the generation of a 2D image by multidimensional comprehensive chromatography (GCxGC). This technique is indeed, with GC-MS, a reference technique for the analysis of complex mixtures that can contain hundreds of compounds some of them at very low concentrations. However, the technique has been little evaluated on this emerging topic of breath analysis, and there is no transportable GCxGC instrument developed for now. The thesis will focus particularly on the development and evaluation of two new key technologies on silicon, allowing in one hand the gas sampling and on the other hand the modulation that enables the images generation. Comparative tests with GC-MS will be performed on patient samples with an active research team in the field. The ideal candidate will have a multidisciplinary profile combining microtechnology, analytical chemistry, instrumentation and biomedical research skills.

This position is open until it is filled.

Department: Département Microtechnologies pour la Biologie et la Santé (LETI)
Laboratory: Laboratoire BioChip et BioPackaging
Start Date: 01-09-2015
ECA Code: SL-DRT-15-0634
Contact: bertrand.bourlon<στο>cea.fr