Postdoctoral Research Fellowship in Bioinformatics (ref no 2014/14416)

Through next-generation sequencing (NGS) of DNA and RNA, in combination with techniques such as ChIP, one can generate genome-wide profiles of a number of features of nuclear DNA, such as histone modifications, chromosome conformations and DNA-binding proteins. Sequencing can also reveal information on genome variation, gene splicing, DNA methylation, and gene expression, to name a few. As most biological processes involve a complex interplay between different types of biological molecules, a natural analytical strategy is to integrate data sets related to such multiple biological features. The integration of data sets enables interrogation of relations between biological molecules and processes in various biological contexts, not least disease.