PhD position in bio-microfluidics

KTH Royal Institute of Technology in Stockholm is the largest and oldest technical university in Sweden. No less than one-third of Swedens technical research and engineering education capacity at university level is provided by KTH. Education and research spans from natural sciences to all branches of engineering and includes Architecture, Industrial Management and Urban Planning. There are a total of 13,400 first and second level students and almost 1,900 doctoral students. KTH has 4,900 employees.

KTH Bioteknologi har som mål att ge en stark kunskapsbas för teoretiska och tillämpade frågeställningar inom livsvetenskaperna. Skolan består av sex avdelningar, genteknologi, glykovetenskap, industriell bioteknologi, proteinteknologi, proteomik och nanobioteknologi samt teoretisk kemi och biologi. Skolans verksamhet är lokaliserad till AlbaNova Universitetscentrum i Stockholm och Science for Life Laboratory i Solna. Vi är cirka 300 anställda, varav många är involverade i bioteknisk forskning på internationell toppnivå. Skolan erbjuder också civilingenjörs- och mastersutbildningar.

The division of Proteomics and Nanobiotechnology at KTH Biotechnology is focusing on interdisciplinary research, and the Nanobiotechnology division combines nanotechnology and microfluidics with various biotechnology and medical applications. The Nanobiotechnology group consists today of approximately 30 people with a wide variety of backgrounds such as electrical engineering, medicine, biotechnology, chemistry and physics creating a very dynamic and interdisciplinary environment. The division is currently focusing on three different areas: droplet microfluidics, clinical microfluidics and point of care systems. The PhD position is within the clinical microfluidics lab, where the research involves development of microfluidic point-of-care devices for blood diagnostics. The group is current research at KTH involves development of microfluidic point-of-care devices for blood diagnostics with focus on sample preparation for sepsis diagnostics, cancer diagnostics, and HIV diagnostics. We are currently developing several microfluidic platforms, including lab-on-DVD and Lab-on-foil systems. In addition, the group is involved in a number of EU FP7 projects.

www.scilifelab.se/researchers/helene-andersson-svahn/


Job description

Background: The HIV/AIDS epidemic remains a major global public health challenge; with more than 34 million people living with HIV and it remains one of the top ten causes of death globally. CD4 cell counts measure the health of the immune system, in HIV-infected patients, and are essential to diagnose, stage and monitor HIV-infected patients. Despite significant technological progress made, diagnostic systems for measuring CD4 counts that are appropriate for resource-limited settings simply do not exist. Today, the lack of appropriate CD4 count has become a critical bottleneck preventing the expansion of efforts to address the AIDS pandemic.

Project description: The project aims to develop a novel platform for molecular and cellular diagnostics, in particular integrated CD4 counter for HIV diagnostics and monitoring of treatment. The system combines (1) optical disks with integrated microfluidics and on-board cell capture reagents with (2) a modified consumer DVD reader for "imaging" of captured cells, equipped with integrated functionality to enable control of liquid handling and cell enumeration software. The work includes both theoretical analysis and practical work in microfabrication in the cleanroom environment, evaluation, and biological characterization of isolated CD4 cells. Work with centrifugal microfluidics and theoretical work, eg with COMSOL, is an advantage.

Qualifications

The requirements are met by the candidate who have passed second-cycle studies, fulfilled course requirements corresponding to at least 240 credits, of which a minimum of 60 credits are for second-cycle studies, or otherwise acquired largely equivalent knowledge either in or outside Sweden. The candidate should be highly motivated for doing scientific research and should have well developed analytical and problem solving skills.

Trade union representatives

You'll find contact information to trade union representatives at KTH:s webbpage .

Application

The application must include following documents:

  1. Curriculum vitae
  2. Official record of transcripts and a copy of degree certificate
  3. Cover letter

Log into KTH's recruitment system in order to apply to this position. You are the main responsible to ensure that your application is complete according to the ad. Your complete application must be received at KTH no later than the last day of application.

Others

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Type of employment: Temporary position longer than 6 months
Working hours: Full time
Salary: Salary follows the guidelines provided by kth
City: Stockholm
Reference number: B-2014-0368
Published: 2014-12-18
Last application date: 2015-01-08


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