Current work is focused on understanding the biological function of proteins involved in regulation of histone and DNA methylation and how they contribute to cancer. Moreover, the group has developed several cancer relevant mouse models that are used both for the understanding of the role of specific proteins in cancer and for the identification of potential novel targets for the development of novel anti-cancer therapies.

The group is using a host of different techniques and model systems to achieve these goals, including loss-of-function screenings, embryonic and adult stem cells, mouse genetics, mass spec analysis, and pathology.

The successful applicants will work on projects related to of our efforts of identifying potential and validating novel targets for the development of anti-cancer therapy. These projects involve the use of clinical relevant model systems in combination with focused shRNA/Crispr viral libraries and the subsequent biological and biochemical characterization of identified genes. Alternatively, the applicants will work on projects related to understanding the role of specific chromatin-associated proteins in transcription and cell-fate determination.

Further details:
http://www.jobsinbrussels.com